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Identification of functional bradykinin B2 receptors endogenously expressed in HEK293 cells

✍ Scribed by Inga I. Kramarenko; Marlene A. Bunni; Thomas A. Morinelli; John R. Raymond; Maria N. Garnovskaya


Book ID
113488641
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
570 KB
Volume
77
Category
Article
ISSN
0006-2952

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon