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Identification of EGFR mutations in lung sarcomatoid carcinoma

✍ Scribed by Alvaro Leone; Paolo Graziano; Rita Gasbarra; Gregorino Paone; Giuseppe Cardillo; Andrea Mancuso; Filippo De Marinis; Serena Ricciardi; Luigi Portalone; Roberto Pisa

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
237 KB
Volume
128
Category
Article
ISSN
0020-7136

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Author's reply to: Identification of EGF
Author's reply to: Identification of EGFR mutations in lung sarcomatoid carcinomas
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We have read with great interest the comments of Leone et al. 1 indicating that they have analyzed a series of 23 cases of lung sarcomatoid carcinomas (SC) and found 2 cases harboring an EGFR mutation. At the time of this writing, 78 cases 1- 7 and 58 cases 1,2,6 of SC have been screened for EGFR an

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## Abstract Sarcomatoid carcinomas (SC) of the lung are uncommon malignant tumors composed of carcinomatous and sarcomatous cell components and characterized by a more aggressive outcome than other histological subtypes of nonsmall cell lung cancer (NSCLC). Although epidermal growth factor receptor

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## Abstract Mutations of the epidermal growth factor receptor gene (__EGFR__) have been reported to be present in a considerable fraction of lung adenocarcinomas showing dramatic response to EGFR tyrosine kinase inhibitors. To clarify pathogenic significance of the mutations for the development of