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EGFR and KRAS mutations in lung carcinoma : Molecular testing by using cytology specimens

✍ Scribed by Shahreen Billah; John Stewart; Gregg Staerkel; Su Chen; Yun Gong; Ming Guo


Publisher
Wiley (John Wiley & Sons)
Year
2011
Tongue
English
Weight
139 KB
Volume
119
Category
Article
ISSN
1934-662X

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## Abstract ## BACKGROUND: Somatic mutations in the epidermal growth factor receptor (__EGFR__) are present in ∼10% of nonsmall cell lung cancers, and higher in never‐smokers, women, and Asians. Small in‐frame deletions in exon 19 (∼45%) and L858R mutation in exon 21 (∼40%) predict response to tre