𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Identification of Diverse Microbial Metabolites as Potent Inhibitors of HIV-1 Tat Transactivation

✍ Scribed by Hiranthi Jayasuriya; Deborah L. Zink; Jon D. Polishook; Gerald F. Bills; Anne W. Dombrowski; Olga Genilloud; Fernando F. Pelaez; Lucia Herranz; Donette Quamina; Russell B. Lingham; Renee Danzeizen; Pia L. Graham; Joanne E. Tomassini; Sheo B. Singh

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
118 KB
Volume
2
Category
Article
ISSN
1612-1872

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

2-Phenylquinolones as Inhibitors of the
2-Phenylquinolones as Inhibitors of the HIV-1 Tat–TAR Interaction
✍ Barbara Gatto; Oriana Tabarrini; Serena Massari; Giulia Giaretta; Stefano Sabati 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 202 KB

## Abstract **Novel 2‐phenylquinolones** aimed at the Tat–TAR complex were synthesized and tested. Derivatives characterized by precise modifications of the quinolone nucleus and to the side chain of the 2‐phenyl ring allowed a thorough structure–activity study, confirming 2‐phenylquinolone as a su

Studies of Anti-HIV Transcription Inhibi
Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-Vinyl Derivatives
✍ Prof. Oriana Tabarrini; Dr. Serena Massari; Dr. Dirk Daelemans; Dr. Francesco Me 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 416 KB

## Abstract __The 6‐desfluoroquinolones (6‐DFQs) are anti‐HIV agents that target Tat‐mediated transcription. This particular mechanism of action makes this class of compounds very attractive for further structural investigations. Identification of the pharmacophore required for inhibition will ulti