Identification of certain chemical agents in complex organic solutions by gas chromatography/tandem mass spectrometry

✍ Scribed by Lei Mei-ling; Xi Hai-ling; Xu Da-nian; Chen Zhi-sheng

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 236 KB
• Volume: 41
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/jms.1116

✦ Synopsis

Abstract

Analytical methods that are used for the detection and identification of chemicals related to the Chemical Weapons Convention in complex organic solutions were developed. A matrix modified by the addition of complex diesel oil background compounds and interferences was used for the development of a gas chromatography‐mass spectrometry or gas chromatography‐tandem mass spectrometry (GC‐MS or GC‐MS/MS) method for unambiguous identification of the scheduled chemicals. Co‐elution of diethyl N,N‐dimethylphosphoramidate and ethyl N,N‐dimethylphosphoramidocyanidate, which are not separated by GC, was identified by GC‐MS. Although GC‐MS can identify the compounds, GC‐MS/MS identification has greater accuracy and sensitivity in the case of complex matrixes. Four scheduled chemicals were accurately and selectively identified against numerous interfering substances by GC‐MS/MS. The fragmentation chemistry of these compounds using MS/MS analysis was investigated. Copyright © 2006 John Wiley & Sons, Ltd.