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Identification of an Opioid κ Receptor Subtype-Selective N-Substituent for (+)-(3 R ,4 R )-Dimethyl-4-(3-hydroxyphenyl)piperidine

✍ Scribed by Thomas, James B.; Fall, Michael J.; Cooper, Julie B.; Rothman, Richard B.; Mascarella, S. Wayne; Xu, Heng; Partilla, John S.; Dersch, Christina M.; McCullough, Karen B.; Cantrell, Buddy E.; Zimmerman, Dennis M.; Carroll, F. Ivy


Book ID
126770475
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
173 KB
Volume
41
Category
Article
ISSN
0022-2623

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Synthesis of N- Substituted 4-(4-Hydroxy
✍ Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; C 📂 Article 📅 2000 🏛 American Chemical Society 🌐 English ⚖ 337 KB

Antagonists at the 1A/2B subtype of the NMDA receptor (NR1A/2B) are typically small molecules that consist of a 4-benzyl-or a 4-phenylpiperidine with an ω-phenylalkyl substituent on the heterocyclic nitrogen. Many of these antagonists, for example ifenprodil (1), incorporate a 4-hydroxy substituent