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Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis

✍ Scribed by Wyatt, Emma E.; Galloway, Warren R. J. D.; Thomas, Gemma L.; Welch, Martin; Loiseleur, Olivier; Plowright, Alleyn T.; Spring, David R.


Book ID
111915349
Publisher
Royal Society of Chemistry
Year
2008
Tongue
English
Weight
147 KB
Volume
40
Category
Article
ISSN
1359-7345

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An alternative synthesis of piritrexim,
✍ Reinhard TroschΓΌtz; Mario Zink; Rainer Gnibl πŸ“‚ Article πŸ“… 1999 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 308 KB

## Abstract An alternative synthesis of the lipophilic antifolate piritrexim (1) is outlined. Starting from ketone 2, treatment with phosphorus oxychloride and dimethylformamide gave the β‐chlorocrotonaldehydes 3__E/Z__, which were reacted with cyanoacetamide (6) in the presence of sodium hydride t