An alternative synthesis of piritrexim,
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Reinhard TroschΓΌtz; Mario Zink; Rainer Gnibl
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Article
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1999
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Journal of Heterocyclic Chemistry
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English
β 308 KB
## Abstract An alternative synthesis of the lipophilic antifolate piritrexim (1) is outlined. Starting from ketone 2, treatment with phosphorus oxychloride and dimethylformamide gave the Ξ²βchlorocrotonaldehydes 3__E/Z__, which were reacted with cyanoacetamide (6) in the presence of sodium hydride t