𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Identification of Amplified Genes in a Patient with Acute Myeloid Leukemia and Double Minute Chromosomes

✍ Scribed by Peter E Crossen; Mary J Morrison; Phil Rodley; Jill Cochrane; Christine M Morris

Book ID
114136919
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
886 KB
Volume
113
Category
Article
ISSN
0165-4608

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Localization of amplified MYC gene seque
Localization of amplified MYC gene sequences to double minute chromosomes in acute myelogenous leukemia
✍ Dr. Marilyn L. Slovak; Jennifer Pelkey Ho; Mark J. Pettenati; Aziz Khan; Daniel πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 506 KB

Cytogenetic and molecular studies were performed on two dmin-bearing acute myelogenous leukemia (FAB-M2) samples. Both cases were characterized by complex karyotypes containing interstitial deletions of the long arm of chromosome 8 altering band 8q24. I, aberrations affecting the short arm of chromo

Amplification of the MLL gene on double
Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome
✍ Berthold Streubel; Peter Valent; Ulrich JΓ€ger; Martin EdelhΓ€user; Hannes Wandt; πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 184 KB πŸ‘ 2 views

Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi

Double minute chromosomes in acute myelo
Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: Identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping
✍ Sheila N.J. Sait; Misbah U. Qadir; Jeffrey M. Conroy; Sei-Ichi Matsui; Norma J. πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 757 KB

## Abstract Double minute chromosomes (dmin) are small chromatin bodies consisting of genes amplified in an extrachromosomal location. dmins are uncommon in hematologic malignancies; they are seen primarily in acute myeloid leukemia, with amplification of the __MYC__ oncogene or, less frequently, t