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Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

โœ Scribed by Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A.


Book ID
119234061
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
488 KB
Volume
55
Category
Article
ISSN
0223-5234

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Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.