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Identification of a signaling complex involving CD2, ζ chain and p59fyn in T lymphocytes

✍ Scribed by Martin Gassmann; Kurt E. Amrein; Nicholas A. Flint; Burkhart Schraven; Paul Burn


Book ID
102828838
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
694 KB
Volume
24
Category
Article
ISSN
0014-2980

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## Abstract Trichostatin A (TSA) is a potent reversible inhibitor of histone deacetylase, and it has been reported to have variable effects on the expression of a number of genes. In this report, we show that TSA suppresses the expression of the T cell receptor ζ chain gene, whereas, it upregulates