Oxidative stress is involved in the heat stress-induced downregulation of TCR ζ chain expression and TCR/CD3-mediated [Ca2+]i response in human T-lymphocytes

High dose of dexamethasone upregulates T

High dose of dexamethasone upregulates TCR/CD3-induced calcium response independent of TCR ζ chain expression in human T lymphocytes

✍ Madhusoodana P. Nambiar; Edith J. Enyedy; Carolyn U. Fisher; Vishal G. Warke; Ge 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB

Glucocorticoids are very potent anti-in¯ammatory and immunosuppressive agents that modulate cellular immune responses, although, the molecular mechanisms that impart their complex effects have not been completely de®ned. We have previously demonstrated that dexamethasone (Dex), a synthetic glucocort