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Identification of a Second SH2-Domain-Containing Protein Closely Related to the Phosphatidylinositol Polyphosphate 5-Phosphatase SHIP

✍ Scribed by Xavier Pesesse; Sandrine Deleu; Florence De Smedt; Lyndsay Drayer; Christophe Erneux


Book ID
115581071
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
376 KB
Volume
239
Category
Article
ISSN
0006-291X

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## Abstract SHIP2 (SH2‐containing inositol polyphosphate 5‐phosphatase 2) is a phosphatidylinositol (3,4,5)‐trisphosphate (PtdIns(3,4,5)P~3~) 5‐phosphatase containing various motifs susceptible to mediate protein‐protein interaction. In cell models, SHIP2 negatively regulates insulin signalling thr