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The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2

โœ Scribed by Isabelle Vandenbroere; Nathalie Paternotte; Jacques E Dumont; Christophe Erneux; Isabelle Pirson


Book ID
117053100
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
231 KB
Volume
300
Category
Article
ISSN
0006-291X

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## Abstract SHIP2 (SH2โ€containing inositol polyphosphate 5โ€phosphatase 2) is a phosphatidylinositol (3,4,5)โ€trisphosphate (PtdIns(3,4,5)P~3~) 5โ€phosphatase containing various motifs susceptible to mediate proteinโ€protein interaction. In cell models, SHIP2 negatively regulates insulin signalling thr