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Identification of a nuclear localization signal in the polo box domain of Plk1

✍ Scribed by Moon-Sing Lee; Yi-Han Huang; Shu-Ping Huang; Ru-Inn Lin; Shu-Fen Wu; Chin Li

Book ID: 113486318
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 573 KB
Volume: 1793
Category: Article
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2009.07.005

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## Abstract **Playing polo**: Small‐molecule inhibitors of polo‐like kinase 1 are mostly ATP‐competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small‐molecule inhibitor of the protein–protein interactions required for Plk1 func