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Identification of a Novel p53 Mutation in JCV-Induced Mouse Medulloblastoma

โœ Scribed by Barbara Krynska; Luis Del Valle; Jennifer Gordon; Jessica Otte; Sidney Croul; Kamel Khalili

Book ID
112273111
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
661 KB
Volume
274
Category
Article
ISSN
0042-6822

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We analyzed the genomic structure and mRNA of the RB and p53 genes in four mouse lymphoid leukemia cell lines (DL-1, DL-5, DL-8, and DL-12). Although no gross structural alteration of the RB gene was observed in any cell line, abnormalities of RB mRNA were detected in at least two cell lines. RB mRN