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Identification of a novel lysine-171 allele in the ovine prion protein (PRNP ) gene

✍ Scribed by X. Guo; D. M. Kupfer; G. Q. Fitch; B. A. Roe; U. DeSilva


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
454 KB
Volume
34
Category
Article
ISSN
0268-9146

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Inherited prion diseases are characterized by mutations in the PRNP gene encoding the prion protein (PrP). As the other sporadic or infectious prion disease forms, they are almost all characterized by the accumulation in the brain of an abnormal misfolded form of the patient's PrP. Brain extracts ca