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Identification of a Drosophila brain-gut peptide related to the neuropeptide Y family

✍ Scribed by Mark R Brown; Joe W Crim; Ryan C Arata; Haini N Cai; Cao Chun; Ping Shen


Book ID
117409415
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
355 KB
Volume
20
Category
Article
ISSN
0196-9781

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The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.