Identification of a consistent breakpoint at chromosome 6q11 in human follicular lymphoma by chromosome microdissection
โ Scribed by X.-Y. Guan; H.E. Zhang; D. Horsman; P.S. Meltzer; J.M. Trent
- Book ID
- 113253849
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 147 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0165-4608
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The t( 14; 18) chromosomal translocation characteristic of follicular lymphoma (FL) juxtaposes the immunoglobulin heavy chain locus (IGH) and the BCU proto-oncogene. The translocation can be readily detected as a non-germline Not1 fragment resolved by pulsed-field gel electrophoresis. A benefit of t
## Abstract Regional deletions of 6q are frequent karyotypic alterations in malignant lymphoma and are associated with an adverse clinical outcome. One such region of recurrent deletion is 6q16โq21; however, the specific genes affected have not been identified. Our objective in this study was to id