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Identification of a cDNA clone specific for the neural cell adhesion molecule AMOG

✍ Scribed by S. Pagliusi; H. Antonicek; S. Gloor; R. Frank; M. Moos; Dr. M. Schachner

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 622 KB
Volume: 22
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490220202

No coin nor oath required. For personal study only.

✦ Synopsis

A cDNA clone of the neural cell adhesion molecule AMOG was isolated from a lambda gtlO library constructed from 8-day-old mouse brain poly(A) + RNA with a 17mer oligonucleotide probe designed from a nonapeptide sequence obtained from tryptic peptides of AMOG. The cDNA clone expressed as a fusion protein that is recognized by polyclonal AMOG antibodies; conversely, polyclonal antibodies prepared against the fusion protein react with AMOG. The clone contains the full sequence derived from the nonapeptide. Of all tissues tested, only brain expresses detectable levels of AMOG by ELISA and Northern blot analyses, indicating a high correlation in expression at the protein and mRNA levels. Both brain and astrocytes express a 3 kb long mRNA, which appears to be encoded by a single gene.

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