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Identification of a Candidate Tumor-Suppressor Gene Specifically Activated during Ras-Induced Senescence

✍ Scribed by Marta Barradas; Efstathios S. Gonos; Zoë Zebedee; Evangelos Kolettas; Charikleia Petropoulou; M.Dolores Delgado; Javier León; Eiji Hara; Manuel Serrano

Book ID
115604193
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
247 KB
Volume
273
Category
Article
ISSN
0014-4827

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## Abstract __Fat__, a candidate tumor suppressor in __Drosophila__, is a component of Hippo signaling pathway involved in controlling organ size. We found that a ∼3 Mbp deletion in mouse chromosome 3 caused tumorigenesis of a non‐tumorigenic mammary epithelial cell line. The expression of __Fat4__