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Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors

โœ Scribed by Yike Ni; Ariamala Gopalsamy; Derek Cole; Yonghan Hu; Rajiah Denny; Manus Ipek; Julie Liu; Julie Lee; J. Perry Hall; Michael Luong; Jean-Baptiste Telliez; Lih-Ling Lin


Book ID
113495996
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
763 KB
Volume
21
Category
Article
ISSN
0960-894X

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โœ Chitra Vaidya; Joel E. Wright; Andre Rosowsky ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 220 KB

## Abstract Three previously undescribed dihydrofolate reductase (DHFR) inhibitors, N^ฮฑ^โ€[4โ€[__N__โ€[(2,4โ€diaminopyrrolo[2,3โ€__d__]pyrimidinโ€5โ€yl)methyl]amino]benzoyl]โ€__N__^ฮด^โ€hemiphthaloylโ€Lโ€ornithine **(7)**, __N__^ฮฑ^โ€ [4โ€ [__N__โ€[(2,4โ€diaminothieno[2,3โ€__d__]pyrimidinโ€5โ€yl)methyl]amino]benzoyl]โ€