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Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I

✍ Scribed by H. Umesha Shetty; Sami S. Zoghbi; Jeih-San Liow; Masanori Ichise; Jinsoo Hong; John L. Musachio; Christer Halldin; Jurgen Seidel; Robert B. Innis; Victor W. Pike


Publisher
Springer
Year
2006
Tongue
English
Weight
311 KB
Volume
34
Category
Article
ISSN
0340-6997

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The cocaine analogue P-CIT-FE (N-(2-fluoroethyl)-2~-carbomethoxy-3~-(4-iodopheny1)nortropane) was labeled with ' lC for positron emission tomography (PET) studies of the dopamine transporter. After intravenous administration to a cynomolgus monkey, ["CIP-CIT-FE accumulated in the striatum with a str