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Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists

✍ Scribed by Nils Griebenow; Lars Bärfacker; Heinrich Meier; Dirk Schneider; Nicole Teusch; Klemens Lustig; Raimund Kast; Peter Kolkhof


Book ID
104004695
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
901 KB
Volume
20
Category
Article
ISSN
0960-894X

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Substituted Pyrazolo[3,4-b]pyridines as
✍ Tiziano Tuccinardi; Silvia Schenone; Francesco Bondavalli; Chiara Brullo; Olga B 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 805 KB

## Abstract Sixty‐eight new substituted pyrazolo[3,4‐b]pyridine derivatives were synthesized and tested for enriching a library of active A~1~ adenosine receptor (AR) antagonists belonging to the same class. These compounds were also used as an external test set to check the reliability of a 3D QSA