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Identification and Mechanism of a Bacterial Hydrolyzing UDP- N -Acetylglucosamine 2-Epimerase †

✍ Scribed by Murkin, Andrew S.; Chou, Wayne K.; Wakarchuk, Warren W.; Tanner, Martin E.


Book ID
118117471
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
133 KB
Volume
43
Category
Article
ISSN
0006-2960

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The ''non-hydrolyzing'' bacterial UDP-N-acetylglucosamine 2-epimerase catalyzes the reversible interconversion of UDP-Nacetylglucosamine (UDP-GlcNAc) and UDP-N-acetylmannosamine (UDP-ManNAc). This homodimeric enzyme is allosterically activated by its substrate, UDP-GlcNAc, and it is thought that one