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Identification and characterization of pseudoirreversible nonpeptide antagonists of the neuropeptide Y Y5 receptor and development of a novel Y5-selective radioligand

✍ Scribed by Deborra Mullins; Nika Adham; David Hesk; Yusheng Wu; Joseph Kelly; Ying Huang; Mario Guzzi; Xiaoping Zhang; Stuart McCombie; Andrew Stamford; Eric Parker

Book ID
113587923
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
807 KB
Volume
601
Category
Article
ISSN
0014-2999

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✍ Gillian E. Lunniss; Ashley A. Barnes; Nick Barton; Matteo Biagetti; Federica Bia πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 678 KB

The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.