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Identification and characterization of olanzapine degradation products under oxidative stress conditions

โœ Scribed by Hiriyanna, S. Hiriyanna; Basavaiah, K.; Goud, P.; Dhayanithi, V.; Raju, K.; Pati, H. Pati

Book ID
118027699
Publisher
Akadmiai Kiad
Year
2008
Tongue
English
Weight
120 KB
Volume
20
Category
Article
ISSN
1233-2356

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Two impurities found in both stressed and aged solid-state formulations of olanzapine have been identified as (Z)-1,3-dihydro-4-(4-methyl-1-piperazinyl)-2-(2-oxopropylidene)-2H-1,5-benzodiazepin-2-one (1) and (Z)-1-[1,2-dihydro-4-(4-methyl-1-piperazinyl)-2-thioxo-3H-1,5-benzodiazepin-3-ylidene]propa