Proteins are susceptible to degradation upon exposure to a variety of stresses during product manufacturing, transportation and storage. In this study, we investigated the aggregation properties of a monoclonal antibody during agitation stress. Agitation exclusively led to insoluble aggregates, or p
Identification and Characterization of Buried Unpaired Cysteines in a Recombinant Monoclonal IgG1 Antibody
โ Scribed by Zhang, Taylor; Zhang, Jennifer; Hewitt, Daniel; Tran, Ben; Gao, Xiaoying; Qiu, Zhihua Julia; Tejada, Max; Gazzano-Santoro, Helene; Kao, Yung-Hsiang
- Book ID
- 111985184
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 816 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0003-2700
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