Characterization of antibody aggregation
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Brych, Stephen R. (author);Gokarn, Yatin R. (author);Hultgen, Heather (author);S
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Article
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2010
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John Wiley and Sons Inc.
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English
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Proteins are susceptible to degradation upon exposure to a variety of stresses during product manufacturing, transportation and storage. In this study, we investigated the aggregation properties of a monoclonal antibody during agitation stress. Agitation exclusively led to insoluble aggregates, or p