Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein
โ Scribed by Ilka Nemere; Susan E. Safford; Benjamin Rohe; Mary M. DeSouza; Mary C. Farach-Carson
- Book ID
- 116697332
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 108 KB
- Volume
- 89-90
- Category
- Article
- ISSN
- 0960-0760
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The rapid, nongenomic effects of 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3 have been related to a 1,25D3-membrane associated, rapid response steroid binding protein or 1,25D3-[MARRS]bp, with a molecular weight of 65 kDa, in several tissues and species. Currently, no information is available c
The steroid hormone Ia,25-dihydroxyvitamin D3 has been shown to exert rapid effects (1 5 s to 5 min) in osteoblasts. These effects occur in osteoblast-like cells lacking the nuclear vitamin D receptor, ROS 24/1, suggesting that a separate signalling system mediates the rapid actions. These non-genom