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Identification and biological activity of novel peptidomimetic gastrin/CCK-B receptor agonists

✍ Scribed by Graeme Semple; Hamish Ryder; David A. Kendrick; Andrzej R. Batt; Elizabeth Mathews; David P. Rooker; Michael Szelke; Akito Nishida; Keiji Miyata

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 310 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00546-x

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✦ Synopsis

The design, synthesis and biological activity of two novel series of compounds derived from the basic Boc-CCK-4 structure which provide potent ligands for the gastrin/CCK-B receptor is outlined. Within these series, new pseudopeptide compounds were discovered which unexpectedly were functional agonists in vivo, as shown by their ability to stimulate basal gastric acid secretion in rats, an effect which was blocked by the potent gastrin/CCK-B receptor antagonist YM022.

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