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Identification and Analysis of the Major M2 Autoantigens in Primary Biliary Cirrhosis

โœ Scribed by Shelley P. M. Fussey, John R. Guest, Oliver F. W. James, Margaret F. Bassendine and Stephen J. Yeaman


Book ID
123636289
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
986 KB
Volume
85
Category
Article
ISSN
0027-8424

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The E2 component of mitochondrial pyruvate dehydrogenase complex (PDC-E2) is the immunodominant autoantigen of primary biliary cirrhosis. Whereas lipoylation of PDC-E2 is essential for enzymatic activity and predominates under normal conditions, other biochemical systems exist that also target the l