Identity of the M2 autoantigens in primary biliary cirrhosis
โ Scribed by Ian R. Mackay; Merrill J. Rowley; John McD. Armstrong
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 281 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0270-9139
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We greatly appreciated the recent article by Ishii et al.
The E2 component of mitochondrial pyruvate dehydrogenase complex (PDC-E2) is the immunodominant autoantigen of primary biliary cirrhosis. Whereas lipoylation of PDC-E2 is essential for enzymatic activity and predominates under normal conditions, other biochemical systems exist that also target the l
Serum autoantibodies against components of nuclear dots (anti-NDs), namely PML and Sp100, are specifically detected in 20% to 30% of patients with primary biliary cirrhosis (PBC). Although anti-ND antibodies are nonpathogenic, the mechanisms that lead to this unique reactivity are critical to unders