## Background: Liposomal encapsulation of daunorubicin (daunoxome, dnx; nexstar pharmaceutical, boulder, co) changes the pharmacology profile to increase delivery to tumor sites and decrease toxicity. the authors investigated the effect of daunorubicin in combination with ara-c in patients with ref
Idarubicin, cytarabine, and topotecan in patients with refractory or relapsed acute myelogenous leukemia and high-risk myelodysplastic syndrome
โ Scribed by Seung Tae Lee; Joon Ho Jang; Hyung Chan Suh; Jee Sook Hahn; Yun Woong Ko; Yoo Hong Min
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 97 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0361-8609
- DOI
- 10.1002/ajh.1188
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Background. The treatment of relapsed and refractory leukemia in children remains a challenge. The morbidity of further chemotherapy is considerable, as most patients have already been exposed to intensive multiagent chemotherapy. The FLAG (fludarabine, high-dose cytarabine, and G-CSF) regimen is as
## FLAG (Fludarabine, High-Dose Cytarabine and G-CSF) for Refractory and High-Risk Relapsed Acute Leukemia in Children We have read with interest the report about FLAG therapy in childhood acute leukemia by McCarthy et al. [1]. We want to add our experience with IDA-FLAG in poor-risk childhood leuk