✦ LIBER ✦

Letter to the Editor:FLAG (fludarabine, high-dose cytarabine and G-CSF) for refractory and high-risk relapsed acute leukemia in children

✍ Scribed by Sarper, Nazan; Yalman, Nevin

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 41 KB
Volume: 34
Category: Article
ISSN: 0098-1532
DOI: 10.1002/(sici)1096-911x(200002)34:2<163::aid-mpo21>3.0.co;2-6

No coin nor oath required. For personal study only.

✦ Synopsis

FLAG (Fludarabine, High-Dose Cytarabine and G-CSF) for Refractory and High-Risk Relapsed Acute Leukemia in Children

We have read with interest the report about FLAG therapy in childhood acute leukemia by McCarthy et al. [1]. We want to add our experience with IDA-FLAG in poor-risk childhood leukemia. Between March 1997-July 1998, we treated 17 patients (3-18 yr) with IDA-FLAG (idarubicin, fludara, cytarabine, G-CSF) [2]. A total of 25 courses were administered. There were six patients with relapsed acute lymphoblastic leukemia (ALL), nine relapsed acute myeloblastic leukemia (AML), one chronic myelomonocytic leukemia (CMML), and one chronic myeloid leukemia (CML) in acute blast crisis. Five of the AML relapses were after

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FLAG (fludarabine, high-dose cytarabine,

FLAG (fludarabine, high-dose cytarabine, and G-CSF) for refractory and high-risk relapsed acute leukemia in children

✍ McCarthy, A.J.; Pitcher, L.A.; Hann, I.M.; Oakhill, A. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 63 KB 👁 1 views

Background. The treatment of relapsed and refractory leukemia in children remains a challenge. The morbidity of further chemotherapy is considerable, as most patients have already been exposed to intensive multiagent chemotherapy. The FLAG (fludarabine, high-dose cytarabine, and G-CSF) regimen is as