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Id4 Expression Induces Apoptosis in Astrocytic Cultures and Is Down-regulated by Activation of the cAMP-Dependent Signal Transduction Pathway

✍ Scribed by Pedro J. Andres-Barquin; Maria-Clemencia Hernandez; Mark A. Israel

Book ID: 115603181
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 275 KB
Volume: 247
Category: Article
ISSN: 0014-4827
DOI: 10.1006/excr.1998.4360

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## Abstract Nitric oxide (NO) from astrocytes is one of the signalers used by the brain's extensive glial‐neuronal‐vascular network, but its excessive production by pro‐inflammatory cytokine‐stimulated glial cells can be cytodestructive. Here, we show how three pro‐inflammatory cytokines (IL‐1β, TN