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Icaritin promotes osteogenic differentiation while inhibits osteoclastic differentiation in vitro

โœ Scribed by Dong Yao; Xinluan Wang; Xinhui Xie; Ge Zhang; Ling Qin


Book ID
116323844
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
67 KB
Volume
47
Category
Article
ISSN
8756-3282

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## Abstract Although osteopontin (OPN) is highly expressed in osteoclasts, OPNโ€deficient mice have a nearโ€normal bone phenotype and its role in osteoclast differentiation and function remains uncertain. We used an adenoviral OPNโ€antisense vector (AdOPNโ€AS) to downโ€regulate OPN expression in a human