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Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro

✍ Scribed by Akira Nakamura; Chi Ly; Mirijana Cipetić; Natalie A. Sims; Jessica Vieusseux; Vicky Kartsogiannis; Stelios Bouralexis; Hasnawati Saleh; Hong Zhou; John T. Price; T. John Martin; Kong Wah Ng; Matthew T. Gillespie; Julian M.W. Quinn

Book ID: 116319822
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 899 KB
Volume: 40
Category: Article
ISSN: 8756-3282
DOI: 10.1016/j.bone.2006.09.001

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## Abstract Although osteopontin (OPN) is highly expressed in osteoclasts, OPN‐deficient mice have a near‐normal bone phenotype and its role in osteoclast differentiation and function remains uncertain. We used an adenoviral OPN‐antisense vector (AdOPN‐AS) to down‐regulate OPN expression in a human