Thirty-seven adult patients with acute lymphoblastic leukemia were treated with a protocol called HEAV'D including Adriamycin, Vincristine, L-Asparaginase, Cyclophosphamide and Dexamethasone. The complete remission rate was 70 per cent. The median duration of remission was more than 30 months. Patie
I17 Treatment of acute lymphoblastic leukemia in adults
✍ Scribed by D. Hoelzer; N. G¨okbuget
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 90 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0268-960X
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✦ Synopsis
Recent treatment strategies in adult ALL mainly include (1) intensification of induction and consolidation chemotherapy, (2) molecular targeting, particularly in Ph/bcr abl pos-ALL, (3) antibody therapy and (4) extension of stem cell transplantation (SCT). New diagnostic tools are used to refine definition of prognostic subgroups and to develop a new risk stratification. They include (5) evaluation of minimal residual disease (MRD) and (6) microarray techniques.
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At the present time, it is possible to achieve up to a 95% complete remission in childhood acute lymphoblastic leukemia, using the combination of vincristine and prednisone. Nevertheless, it has not been possible to reproduce these results in the adult. For this reason, a third drug, in this case a
## Abstract This report describes the results of a study of central nervous system (CNS) prophylaxis and combination chemotherapy for the maintenance of remission in adult acute lymphoblastic leukemia. Adults with acute lymphoblastic leukemia who achieved complete remission were treated with 2,400
To the Editor: Blast cells of <2% of cases of pediatric B-progenitor cell