High-dose therapy with autologous stem cell transplantation (ASCT) has been extensively used in the past 15 years in multiple myeloma. The IFM 90 trial has shown that autologous bone marrow transplantation (BMT) is superior to conventional chemotherapy in terms of response rate, event free survival,
I04 Stem cell transplantation in multiple myeloma
โ Scribed by G. Gahrton
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 59 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0268-960X
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## Abstract ## BACKGROUND Multiple myeloma (MM) is the most common indication for highโdose chemotherapy with autologous stem cell transplantation (ASCT) in the U.S. and can be associated with substantial morbidity. Thorough assessment and understanding of symptoms and risk factors for symptom dev
## Abstract Autologous stem cell transplantation (ASCT) has enabled the use of highโdose alkylating agents either as a single agent or in combination with other cytotoxic agents and/or total body irradiation (TBI) for the treatment of multiple myeloma. Despite improved complete remission rates, rel