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Hypoxia upregulates cyclooxygenase-2 and prostaglandin E2 levels in human peritoneal fibroblasts

✍ Scribed by Ghassan M. Saed; Adnan R. Munkarah; Husam M. Abu-Soud; Michael P. Diamond

Book ID
118445149
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
123 KB
Volume
83
Category
Article
ISSN
1556-5653

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## Abstract ## Objective To elucidate the mechanism of basic calcium phosphate (BCP) crystal–induced prostaglandin E~2~ (PGE~2~) production in human foreskin fibroblasts (HFFs), to identify the signaling pathway involved in the induction of cyclooxygenase 2 (COX‐2) messenger RNA (mRNA) by BCP crys