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Hypoxia-inducible factor and cancer

✍ Scribed by Luis del Peso


Book ID
110646218
Publisher
Springer Milan
Year
2004
Tongue
Spanish
Weight
196 KB
Volume
6
Category
Article
ISSN
1699-048X

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## Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increa