Hypoxia-inducible factor 1 and cancer pa
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Gregg L. Semenza
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Article
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2008
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John Wiley and Sons
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English
β 235 KB
## Abstract Hypoxiaβinducible factor 1 (HIFβ1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIFβ1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIFβ1 activates the transcription of genes that increa