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Hypoxia-inducible factor-1alpha suppressing apoptosis and increasing tolerance of lung cancer cells to chemotherapy

✍ Scribed by Wanguang Zhang; Huilan Zhang


Book ID
107405428
Publisher
Springer-Verlag
Year
2006
Tongue
Chinese
Weight
95 KB
Volume
26
Category
Article
ISSN
0510-9752

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## Abstract Hypoxia‐inducible factor (HIF)‐1Ξ± is the regulatory subunit of HIF‐1 that is stabilized under hypoxic conditions. Under different circumstances, HIF‐1Ξ± may promote both tumorigenesis and apoptosis. There is conflicting data on the importance of HIF‐1Ξ± as a prognostic factor. This study