In humans, cerebral hypoxia is a common component of severe brain insults, including trauma, stroke, and perinatal asphyxia. Oxidative stress and free radicals incidental to cerebral hypoxia are implicated in damaging macromolecules, leading to collapse of cellular homeostasis and cell death. Neuron
Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis
β Scribed by Monika Biniecka; Edward Fox; Wei Gao; Chin Teck Ng; Douglas J. Veale; Ursula Fearon; Jacintha O'Sullivan
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 302 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To investigate the effect of statins on vascular dysfunction in rat adjuvantβinduced arthritis (AIA). ## Methods Fluvastatin (5 mg/kg/day) was administered orally to rats with AIA, for 21 days after the onset of arthritis. The vasodilatory response to acetylcholine of ao