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Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression

✍ Scribed by Semenza, Gregg L.


Book ID
121404683
Publisher
Informa plc
Year
2000
Tongue
English
Weight
443 KB
Volume
35
Category
Article
ISSN
1040-9238

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## Abstract Oxygen‐dependent regulation of HIF‐1 activity occurs at multiple levels in vivo. The mechanisms regulating HIF‐1Ξ± protein expression have been most extensively analyzed but the ones modulating HIF‐1 transcriptional activity remain unclear. Changes in the phosphorylation and/or redox sta