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Hypothermic Protection in Rat Focal Ischemia Models: Strain Differences and Relevance to ???Reperfusion Injury???

✍ Scribed by Ren, Yubo; Hashimoto, Megumi; Pulsinelli, William A.; Nowak,, Thaddeus S.


Book ID
110088629
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
508 KB
Volume
24
Category
Article
ISSN
0271-678X

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This study investigated the effects of dual endothelin (ET) receptor blockade in rat models of liver ischemia and reperfusion injury (IRI). Three models of IRI were used: (1) in vivo total hepatic warm ischemia with portal shunting for 60 minutes with control (saline) and treatment groups (15 mg/kg