Hypothalamic indomethacin fails to block fever induced in rats by central macrophage inflammatory protein-1 (MIP-1)
✍ Scribed by F.J. Miñano; M. Vizcaino; R.D. Myers
- Book ID
- 113224389
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 559 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0091-3057
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The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-lP, induce an intense fever in the rat when they are injected directly into the anterior hypothalamic, pre-optic area (AH/ POA), a region containing thermosensitive neurons. The purpose of this study was to compare the cen