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Hypotensive 1,2-Benzisothiazole 1,1-Dioxides. I. Pyrazole and Pyrazoline Derivatives

✍ Scribed by Traverso, John J.; Whitehead, Calvert W.; Bell, James F.; Boaz, Harold E.; Willard, Paul W.


Book ID
127164909
Publisher
American Chemical Society
Year
1967
Tongue
English
Weight
613 KB
Volume
10
Category
Article
ISSN
0022-2623

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## Abstract An improved and general synthesis of saccharin methylthio and methylsulfone derivatives from chlorosubstituted saccharins is presented. A large‐scale procedure for preparation of chloro‐substituted saccharins was developed. Treatment of the saccharin chlorides with sodium thiomethoxide