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Synthesis and antimicrobial properties of 3-substituted 1, 2-benzisothiazole 1, 1-dioxides

✍ Scribed by Gerald L. Bachman; Joseph W. Baker; Daniel P. Roman

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
258 KB
Volume
67
Category
Article
ISSN
0022-3549

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## Abstract An improved and general synthesis of saccharin methylthio and methylsulfone derivatives from chlorosubstituted saccharins is presented. A large‐scale procedure for preparation of chloro‐substituted saccharins was developed. Treatment of the saccharin chlorides with sodium thiomethoxide