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Hypocretin (orexin) loss in Alzheimer's disease

✍ Scribed by Rolf Fronczek; Sarita van Geest; Marijke Frölich; Sebastiaan Overeem; Freek W.C. Roelandse; Gert Jan Lammers; Dick F. Swaab

Book ID
116781709
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
762 KB
Volume
33
Category
Article
ISSN
0197-4580

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✍ Christian R. Baumann; Claudio L. Bassetti; Philipp O. Valko; Johannes Haybaeck; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 430 KB 👁 1 views

## Abstract Chronic, daytime sleepiness is a major, disabling symptom for many patients with traumatic brain injury (TBI), but thus far, its etiology is not well understood. Extensive loss of the hypothalamic neurons that produce the wake‐promoting neuropeptide hypocretin (orexin) causes the severe